Inherited Predisposition to Cancer? A Dermatoglyphic Study
نویسندگان
چکیده
منابع مشابه
Polygenic inherited predisposition to breast cancer.
The known breast cancer predisposing genes account for only about 20% of inherited susceptibility. Epidemiological analyses suggest that much of the remaining 80% is explained by the combined effect of many individually weak genetic variants, rather than by further rare, highly penetrant mutations. In the near term, identification of variants may indicate new pathways or mechanisms in breast ca...
متن کاملLeading article Inherited predisposition to pancreatic cancer
Pancreatic cancer is the fifth leading cause of death from cancer in men and women in Europe and North America. The prognosis has not changed significantly despite improvements in diagnosis and perioperative management. Traditional chemotherapy and radiotherapy regimens have been rather ineVective in providing control of the disease. The only consistent risk factor identified so far is smoking ...
متن کاملLeading article Inherited predisposition to pancreatic cancer
Pancreatic cancer is the fifth leading cause of death from cancer in men and women in Europe and North America. The prognosis has not changed significantly despite improvements in diagnosis and perioperative management. Traditional chemotherapy and radiotherapy regimens have been rather ineVective in providing control of the disease. The only consistent risk factor identified so far is smoking ...
متن کاملInherited predisposition to glioma.
In gliomas, germline gene alterations play a significant role during malignant transformation of progenitor glial cells, at least for families with occurrence of multiple cancers or with specific hereditary cancer syndromes. Scientific evidence during the last few years has revealed several constitutive genetic abnormalities that may influence glioma formation. These germline abnormalities are ...
متن کاملInherited predisposition to colorectal cancer: towards a more complete picture.
Colorectal carcinoma (CRC) is the third most common cancer worldwide. Hereditary factors are important in 15%-35% of affected patients. This review provides an update on the genetic basis of inherited predisposition to CRC. Currently known genetic factors include a group of highly penetrant mutant genes associated with rare mendelian cancer syndromes and a group of common low-penetrance alleles...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1973
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1973.135